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antiplatelet aggregation plants

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Plant Alkaloids as Antiplatelet Agent: Drugs of the Future ...

 · The commonly used antiplatelet, aspirin, originated from salicin obtained from willow plant commonly used in pain medication. This review describes various alkaloids isolated from plant sources having antiplatelet activity with possible mechanisms and candidates for further detailed studies in the drug discovery as antiplatelet agents.

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Journal of Herbs, Spices & Medicinal Plants

In the antiplatelet aggregation inhibitory activity, the oil displayed action against the induced platelet aggregation in the order collagen (IC 50 < 1) > thrombin (IC 50 1.18) > Adenosine diphosphate (IC 50 2.32) > epinephrine (IC 50 3.65). The lethal concentration (LC 50) …

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Preliminary Studies on Anticoagulation and Antiplatelet ...

Preliminary Studies on Anticoagulation and Antiplatelet Activities of Plinia cauliflora (Mart.) Kausel Leaves Extract ... Borgeat, 2013). Medicinal plants are natural resources, yielding valuable herbal products which are often used in the treatment of ... and its decreasing aggregation via synthesis of cAMP, and the increased concentration of ...

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Inhibitory Effect of Lantana camara L., Eclipta prostrata ...

If the rupture is very large, then most likely there will be a blockage in the large blood vessels. 1 The formation of such thrombus is medically preventable with antiplatelet aggregation agents. Some of medicinal plants from Indonesia have hemostasis-related activities e.g Lantana camara L., Eclipta prostrata (L.) L.) dan Cosmos caudatus Kunth).

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Antiplatelet drugs - list of drugs, indications, side ...

History. Antiplatelet drugs are widely used to prevent arterial thrombosis in various cardiovascular-related conditions. Acetylsalicylic acid (aspirin), is a famous drug used since ancient times, and even then it was known that plants which contain salicylate such as willow can reduce the pain and fever.In 1897, a German scientist Felix Hoffman who was working for Bayer has synthesized aspirin.

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Tropical Journal of Pharmaceutical Research

In this present study, the antiplatelet aggregation activity and cytotoxic effect of the mixture of BA/OA, BAA/OAA as well as MA/OA were investigated. Methods. Reagents. Unless otherwise stated, all reagents were purchased from Sigma-Aldrich and were of analytical grade. Plant materials

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Cujete, Crescentia cujete, Calabash tree: Philippine ...

• Antiplatelet Aggregation Activity /Flavonoid / Fruit: Study investigated C. cujete fruit for flavonoid content and platelet aggregation activity. Results showed potent antiplatelet aggregation activity which was attributed to flavonoid content. Acute oral toxicity categorized it as non-toxic based on OECD guidelines-423. (32)

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Antiplatelet aggregation activity of diterpene alkaloids ...

japonica var. incisa, was found to selectively inhibit rabbit platelet aggregation induced by arachidonic acid in vitro and ex vivo and that the inhibition was much stronger than that of aspirin (Shen et al., 2000). In the present study, the antiplatelet aggregation activities of …

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Comparative Study of Natural Phenolic Acids and Flavonols ...

scavenging activity, antiplatelet and anti-inflammatory activity, in vitro. Specifically, the phenolic compounds were tested for their antioxidant activity, using the DPPH method, for their effect on human platelet aggregation induced, by collagen, ADP and subsequently against …

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Antiplatelet activity of white and pink Nelumbo nucifera ...

Antiplatelet activity of white and pink Nelumbo nucifera Gaertn flowers 581 CaCl2 at a final concentration of 2μM. Platelet aggregation was recorded by increasing transmittance value of spec-trophotometric measurements. To determine the in vitro antiplatelet aggregation property, …

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Cytotoxic and Antiplatelet Aggregation Principles of Ruta ...

The structural elucidation of these isolated compounds were determined by the spectroscopic methods and/or comparison of the physical data with literature values. Their antiplatelet aggregation and cytotoxic activities were examined to find potent antiplatelet aggregation and cytotoxic compounds from natural resources.

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Medicinal Herbals with Antiplatelet Properties Benefit in ...

Medicinal Herbals with Antiplatelet Properties Benefit in Coronary Atherothrombotic Diseases. ... There are a lot of plants that exhibit antiplatelet properties. ... "Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation," Thrombosis Research, vol. 103, no. 5, ...

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Plant Alkaloids as Antiplatelet Agent: Drugs of the Future ...

Antiplatelet mechanism of plant alkaloids. Various mechanisms have been proposed for the antiplatelet activity of different isolated plant-alkaloids (Figure (Figure1). 1).Researchers have proposed that berberine significantly inhibited platelet aggregation by inhibiting synthesis of thromboxane A2 induced by adenine diphosphate, arachidonic acid, collagen (Chu et al., 1996).

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(PDF) Antiplatelet actions of aporphinoids from formosan ...

Antiplatelet actions of aporphinoids from formosan plants. Bioorganic & Medicinal Chemistry Letters, 1999. Che-ming Teng. Yi-chen Chia. Keh-shaw Chen. Ya-ling Chang. Che-ming Teng. Yi-chen Chia. Keh-shaw Chen. Ya-ling Chang. Download with Google Download with Facebook or download with email.

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Cujete, Crescentia cujete, Calabash tree: Philippine ...

• Antiplatelet Aggregation Activity /Flavonoid / Fruit: Study investigated C. cujete fruit for flavonoid content and platelet aggregation activity. Results showed potent antiplatelet aggregation activity which was attributed to flavonoid content. Acute oral toxicity categorized it as non-toxic based on OECD guidelines-423. (32)

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Medicinal Plants with Antiplatelet Activity - El Haouari ...

The identification and/or structure modification of the plant constituents and the understanding of their action mechanisms will be helpful in the development of new antiplatelet agents based on medicinal plants which could contribute to the prevention of thromboembolic‐related disorders by inhibiting platelet aggregation.

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COMPARATIVE FUNCTION-STRUCTURAL ANALYSIS OF …

Guo et al., J. Anim. Plant Sci. 24(3):2014 926 COMPARATIVE FUNCTION-STRUCTURAL ANALYSIS OF ANTIPLATELET AND ANTIRADICAL ACTIVITIES OF FLAVONOID PHYTOCHEMICALS Chunmei Guo, Shuqing Liu*, Yimeng Guo, Yuling Yin, Jintao Lin, Xin Chen and Ming-Zhong Sun

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How Cancer Spreads By Aggregating Platelets -- ScienceDaily

 · Scientists have provided new details about how cancer cells spread by surrounding themselves with platelets -- the blood cells needed for blood …

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In vitro screening of Amazonian plants for hemolytic ...

medicine. So, these data serve as a baseline or minimum of antiplatelet and hemolytic activities (and potential usefulness) of non-medicinal plants from the Amazon forest. Finally, in general, these are the first data on hemolytic and inhibitory activity on platelet aggregation for the genera which these plant species represent.

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Medicinal Plants with Antiplatelet Activity.

The identification and/or structure modification of the plant constituents and the understanding of their action mechanisms will be helpful in the development of new antiplatelet agents based on medicinal plants which could contribute to the prevention of thromboembolic-related disorders by inhibiting platelet aggregation.

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An Overview of Medicinal Plants as Potential Anti-Platelet ...

An Overview of Medicinal Plants as Potential Anti-Platelet Agents Mridul Bhowal1, Darshika M Mehta2 1B Pharm, PES College of Pharmacy, 50 feet road, Hanumanthanagar, ... Chang FR, Wei JL, Teng CM, and Wu YC, Antiplatelet aggregation constituents from Annona purpurea, J …

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aggregation activity antiplatelet

antiplatelet aggregation plants - villa-romano.eu. Antiplatelet activity of Phyllanthus niruri Linn. are no reports on analysis on antiplatelet aggregation activity from this plant …

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In Vitro Antiplatelet Aggregation Activity of Centella ...

Then, exploration of medicinal plants which have cardioprotective activity especially as antiplatelet aggregation agent are needed. One of the medicinal plant, Centella asiatica (L.) Urban, has been known to keep people's health. This study was undertaken to investigate anti-platelet aggregation activity of Centella asiatica ethanolic extract ...

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Antiplatelet aggregation triterpene saponins from the ...

Short communication Antiplatelet aggregation triterpene saponins from the leaves of Ilex kudingcha Bao b Yangb,1, Tao Yangb,1, Qinglong Tanb, Jinping Zhub, Lian Zhoub, Tianqin Xiongb, Zhongxiang Zhao,*, Jing Jina ** aSchool b of Pharmaceutical Sciences, Sun …

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Anti-platelet aggregation assay and chemical composition ...

Anti-platelet aggregation assay and chemical composition of essential oil from Allium atroviolaceum Boiss growing in Iran Zahra Lorigooini 1,4, Farzad Kobarfard 2,3*, Seyed Abdolmajid Ayatollahi 1,3 1Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of …

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In Vitro Platelet Aggregation Inhibition Activity of ...

the percent antiplatelet activity with the succeeding formula: % Inhibition of Platelet Aggregation = The percent inhibition of platelet aggregation values compares the absorbance readings among treated (with plant extract or aspirin) controls and the untreated control. Percent Antiplatelet Activity

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List of Platelet aggregation inhibitors

Platelet aggregation inhibitors work in different places of the clotting cascade and prevent platelet adhesion, therefore no clot formation. Aspirin, the most commonly used antiplatelet drug changes the balance between prostacyclin (which inhibits platelet aggregation) and thromboxane (that promotes aggregation).

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In vitro antiplatelet activity-guided fractionation of ...

 · To determine the in vitro antiplatelet aggregation property, 100 μl of the various fractions of the plant, in different concentrations (100 μg/ ml, 200 μg/ml, 400 μg/ml, 500 μg/ml), respectively was added to the platelet suspension at different concentrations for 1 min exposure at 37° before treatment with platelet aggregating agents ...

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Antiplatelet aggregating activity of extracts of ...

Request PDF on ResearchGate | Antiplatelet aggregating activity of extracts of Indonesian medicinal plants I | Eight Indonesian medicinal plants (Cassia alata L., Cyclea barbata Miers, Imperata ...

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Handbook of Compounds with Anti-Inflammatory and Anti ...

This book presents 848 compounds isolated and identified from plants that present anti-inflammatory and antiplatelet aggregation activities. These substances have been classified by chemical groups and each provides the most relevant information of its pharmacological activity, action mechanism, chemical structure, spectroscopic date, and other properties.

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